Oncology Frontier: In your observations of the markers and databases， have you noticed any ethnic trends， and more specifically， can you discuss Asian populations and the incidence of gastrointestinal cancer?

　　《肿瘤瞭望》：根据您的数据库的记载，胃肠癌症的发病有无种族特征，能否谈一谈亚洲人的胃肠道癌发病率和预测治疗疗效的标志物？

　　Dr Mansfield: In Asian countries， the incidence of gastric cancer is many-fold higher than it is in the United States. As a matter of fact， it is an interesting dynamic that in the US， gastric cancer used to be the most common type of cancer similar to how it is in China， Korea and Japan. But sixty or so years ago， the incidence dramatically began to drop. There are many reasons including cultural， dietary and food preservation issues that appear to have had some impact. So it is a very common disease in those countries. There are some differences as far as responsiveness to certain types of chemotherapy based on differences in body metabolism with genetic correlations. Chemotherapy such as S1 is much more likely to work in an Asian patient than in a Caucasian patient.

　　Mansfield博士：亚洲国家的胃癌发病率是美国的好几倍。虽然胃癌曾经也是美国的常见癌种，但60多年来美国的胃癌发病急剧下降，其原因是多方面的，包括文化、饮食和食物保鲜的问题。由于遗传相关的体内新陈代谢的差异，亚洲人和白种人在对化疗方案的响应方面有差异，比如S-1化疗方案适于亚洲患者。