Oncology Frontier: Your focus is as a surgical oncologist. Can you tell us where your discipline of surgical oncology fits into the spectrum of many different disciplines?

　　《肿瘤瞭望》：您的研究领域是肿瘤外科，能否谈一谈您在相关领域所做的工作？

　　Dr Mansfield: My interests are cancer of the stomach and cancer of the appendix. We have sessions at this meeting on the lower GI cancers which includes the appendix， and for the upper GI cancers including the esophagus， stomach and the GE junction. A lot of the trials I have been involved with have looked at the combination of chemotherapy， radiation therapy， surgery and various combinations before surgery. There have also been clinical trials looking at intraperitoneal therapy for these patients as that is a common area of failure. For appendiceal or peritoneal malignancies， we have another set of clinical trials and we have also developed a database that can help guide treatment and monitoring decisions. For example， we have a large prospective database of patients with cancer of the appendix. We have about 800 patients in that and it enables us to determine things such as how frequently the disease developed in the chest. It turned out to be a lot more frequently than most people recognized which changes the types of tests we would do before providing definitive treatment. It also enables us to understand the prognosis of someone who has a relatively rare type of tumor within that spectrum and to look at factors such as tumor markers that may help predict who is more likely to fail treatment or survive.

　　Mansfield博士：我的研究兴趣是胃癌和阑尾癌。本次会议所涵盖的下消化道癌症包括我研究领域里的阑尾癌，上消化道癌症里包括食道、胃癌和胃食管交界瘤肿瘤。我参与了相当多的化疗、放疗、手术联合治疗试验，及术前各种联合治疗方案的试验。也有一些癌症腹膜内治疗的临床试验。在阑尾癌或腹膜恶性肿瘤方面，我们还开发了一个数据库，以指导治疗方案的选择及监测治疗效果。例如，我们有一个包含800例阑尾癌患者的大型前瞻性数据库，通过数据库，我们可以检测阑尾癌胸部转移率，我们发现胸部转移率比预想要高出很多，我们的检测结果改变了治疗前检查选项。通过数据库还可以更好地监测罕见肿瘤的预后，预测治疗疗效，或找出与患者生存相关的肿瘤标志物。